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Perceptual Disorders clinical trials at UC Davis
1 research study open to eligible people

  • A Study of Exposure to Sedative Medication and Long-Term Cognitive Development in Children

    “Evaluating the effect of sedation on long-term cognitive development”

    open to eligible people ages 30 months to 13 years

    The purpose of this study is to determine the relationships between sedative exposure during pediatric critical illness and long-term neurocognitive outcomes. We will test for drug- and dose-dependent relationships between sedative exposure and neurocognitive outcomes along the early developmental spectrum and will control for baseline and environmental factors, as well as the severity and course of illness. Hypotheses: 1. Greater exposure to benzodiazepines and/or ketamine will be associated with lower IQ even when controlling for severity of illness, hospital course, and baseline factors. In addition, benzodiazepines and/or ketamine will negatively affect other aspects of neurocognitive function. 2. Younger children exposed to benzodiazepines and/or ketamine will have worse neurocognitive outcomes than older children with similar sedative exposure and severity of illness.

    Sacramento, California and other locations

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