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Sickle Cell Anemia clinical trials at UC Davis

3 research studies open to eligible people

Showing trials for
  • Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients

    open to eligible people ages 6 months to 17 years

    The purpose of the Phase 2 CSEG101B2201 study is to confirm and to establish appropriate dosing and to evaluate the safety in pediatric participants ages 6 months to <18 years with a history of VOC with or without HU/HC, receiving crizanlizumab for 2 years. The efficacy and safety of crizanlizumab was already demonstrated in adults with sickle cell disease. The approach is to extrapolate from the PK/pharmacodynamics (PD) already established in the adult population. The study is designed as a Phase II, multicenter, open-label study.

    Sacramento, California and other locations

  • BIVV003 for Autologous Hematopoietic Stem Cell Transplantation in Patients With Severe Sickle Cell Disease

    open to eligible people ages 18-40

    This is an open label, multicenter, Phase 1/2 study in approximately eight adults with severe Sickle Cell Disease (SCD). The study will evaluate the safety, tolerability, and efficacy of autologous hematopoietic stem cell transplantation using BIVV003.

    Sacramento, California and other locations

  • Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)

    “We are looking for people age 12 to 65 years old with SCD to help test a drug trying to reduce the number of vaso-occlusive crises”

    open to eligible people ages 12-65

    This clinical trial is a Phase 2/3 study that will evaluate the efficacy and safety of etavopivat and test how well etavopivat works compared to placebo to improve the amount of hemoglobin in the blood and to reduce the number of vaso-occlusive crises (times when the blood vessels become blocked and cause pain).

    Sacramento, California and other locations

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