A Study of Experimental Oncology Therapies Combined With Chemotherapy and Bevacizumab for Colorectal Cancer
a study on Colorectal Cancer
COLUMBIA-1 is a Phase 1b/2 platform study to evaluate the safety and efficacy of standard of care (FOLFOX plus bevacizumab) alone and in combination with novel oncology therapies in first-line metastatic microsatellite-stable colorectal cancer (MSS-CRC).
A Phase 1b/2, Open-label, Multicenter Study of Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First-line Therapy in Metastatic Microsatellite-stable Colorectal Cancer (COLUMBIA-1)
COLUMBIA-1 is a Phase 1b/2, open-label, multicenter, randomized, multidrug platform study to evaluate the safety and efficacy of standard of care (FOLFOX plus bevacizumab) in combination with novel oncology therapies in patients with first-line metastatic MSS-CRC. The study is designed to concurrently evaluate potential novel combinations with clinical promise using a 2-part approach. Part 1 is a Phase 1b study of safety, and Part 2 is a Phase 2 study of efficacy and safety.
Metastatic Microsatellite-stable Colorectal Cancer Microsatellite colorectal MSS-CRC colon cancer Colorectal Neoplasms Leucovorin Folic Acid Bevacizumab Durvalumab Oxaliplatin Fluorouracil Levoleucovorin Experimental
You can join if…
Open to people ages 18-101
- Written informed consent and any locally required authorization obtained from the subject/legal representative prior to performing any protocol-related procedures, including screening evaluations.
- Age ≥ 18 years at the time of screening.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
- Subjects must have histologic documentation of advanced or metastatic CRC and: (a) A documented mutation test during screening and confirmed tumor locations from disease assessment for enrollment. (b) Subjects must NOT have defective DNA mismatch repair (MSI) as documented by testing. (c) Subjects must not have received any prior systemic therapy for recurrent/metastatic disease (prior adjuvant chemotherapy or radio-chemotherapy is acceptable so long as progression was not within 6 months of completing the adjuvant regimen).
- Subjects must have at least one lesion that is measurable by RECIST v1.1 (Eisenhauer et al, 2009).
- Subjects must have adequate organ function.
- Subjects with medical conditions requiring systemic anticoagulation (eg, atrial fibrillation) are eligible provided that both of the following criteria are met: - The subject has an in-range INR on a stable dose of oral anticoagulant or be on a stable dose of low molecular weight heparin. - The subject has no active bleeding or pathological condition that carries a high risk of bleeding.
8 Body weight >35 kg. 9. Adequate method of contraception per protocol
You CAN'T join if...
- History of allogeneic organ transplantation.
- Active or prior documented autoimmune disorders within the past 5 years.
- History of venous thrombosis within the past 3 months.
- Cardiovascular criteria: (a) Presence of acute coronary syndrome including myocardial infarction or unstable angina pectoris, other arterial thrombotic event including cerebrovascular accident or transient ischemic attack or stroke within the past 6 months. (b) New York Heart Association (NYHA) class II or greater congestive heart failure, serious cardiac arrhythmia requiring medication, or uncontrolled hypertension. (c) History of hypertensive crisis/hypertensive encephalopathy within the past 6 months.
- Mean QT interval corrected for heart rate using Fridericia's formula (QTcF) ≥ 470 ms.
- No significant history of bleeding events or gastrointestinal perforation.
- Uncontrolled intercurrent illness.
- History of another primary malignancy except for: (a) Malignancy treated with curative intent and with no known active disease ≥ 5 years of low potential risk for recurrence. (b) Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease. (c) Adequately treated carcinoma in situ without evidence of disease.
- History of active primary immunodeficiency.
- . Active infection including tuberculosis, hepatitis B, hepatitis C, or human immunodeficiency virus.
- . Known allergy or hypersensitivity to any of the study drugs or any of the study drug excipients.
- . Any unresolved toxicity NCI CTCAE Grade > 1 from previous anticancer therapy.
- . History of leptomeningeal disease or cord compression.
- . Untreated central nervous system (CNS) metastases.
- . Lack of physical integrity of the upper gastrointestinal tract, malabsorption syndrome, or inability to take oral medication.
- . Known dihydropyrimidine dehydrogenase (DPD) deficiency.
- . Prior immunotherapy or anti-angiogenics.
- . Receipt of live attenuated vaccine within the past 30 days.
- . Major surgical procedure, open biopsy, or significant traumatic injury within the past 28 days.
- . Current or prior use of immunosuppressive medication within the past 14 days, with exceptions per protocol.
- Research Site
accepting new patients
Sacramento California 95817 United States
- Research Site
not yet accepting patients
Los Angeles California 90095 United States
Please contact me about this study
We will not share your information with anyone other than the team in charge of this study. Submitting your contact information does not obligate you to participate in research.
The study team should get back to you in a few business days.