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Alpha 1-Antitrypsin Deficiency clinical trials at UC Davis

3 research studies open to eligible people

Showing trials for
  • A Study of Experimental INBRX-101 in Adults With Alpha-1 Antitrypsin Deficiency

    open to eligible people ages 18-80

    This is an open-label, 2-part, dose-escalating, Phase 1 study of INBRX-101 (rhAAT-Fc). Part 1 will consist of single ascending dose (SAD) administration of INBRX-101 and Part 2 will consist of multiple ascending dose (MAD) administrations of INBRX-101. The planned dosing schedule is IV every 3 to 4 weeks.

    Sacramento, California and other locations

  • A Study of the Experimental Medicine Alvelestat (MPH966) for Chronic Obstructive Pulmonary Disease (COPD)

    open to eligible people ages 18-75

    The purpose of this study is to investigate the effect of alvelestat (an oral neutrophil elastase inhibitor) on blood and sputum biomarkers in patients with PiZZ, null or rare variant phenotype/genotype alpha-1 anti-trypsin deficient lung disease. Change in a number of different blood and sputum biomarkers related to lung damage, inflammation and elastase activity will be measured over a 12 week period. The effect on lung function and respiratory symptoms will also be measured.

    Sacramento, California and other locations

  • Safety, Tolerability, and Effect of Experimental ARO-AAT on the Liver and Blood For Alpha-1 Antitrypsin (AAT) Deficiency

    open to eligible people ages 18-75

    The purpose of AROAAT2001 (SEQUOIA) is to evaluate the safety, efficacy and tolerability of multiple doses of the investigational product, ARO-AAT, administered subcutaneously to participants with alpha-1 antitrypsin deficiency (AATD).

    Sacramento, California and other locations

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