Deep Brain Stimulation clinical trials at UC Davis
4 in progress, 2 open to eligible people
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
“Hope for Treatment Resistant Depression with TRANSCEND”
open to eligible people ages 22-70
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.
Sacramento, California and other locations
Dual Frequency Stimulation in Parkinson's Disease
open to eligible people ages 18 years and up
Deep brain stimulation (DBS) in the dorsal region of the subthalamic nucleus (STN) is very effective for reducing motor symptoms of Parkinson's disease (PD). Modeling studies suggest that this therapy may result in current spread into the ventral STN, causing altered cognitive processes. As a result, current stimulation parameters often lead to worsening in verbal fluency, executive function, and, particularly, cognitive control. There is evidence suggesting that low frequency oscillatory activity occurs across brain circuits important in integrating information for cognition. Preclinical studies and human recording studies indicate these low frequency theta oscillations drive cognitive control during cognitive tasks. Thus, the purpose of this study is to determine the safety, tolerability, and efficacy of low frequency stimulation (LFS) of the ventral STN alongside standard high frequency stimulation (HFS) of the dorsal STN in patients with PD.
Sacramento, California
Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation
Sorry, in progress, not accepting new patients
The purpose of the ROAM-DBS study is to compare the time needed to achieve a 1 point improvement Patient's Global Impression of change (PGIC) relative to the subject's status at the end of the ADROIT initial programming visit in subjects who receive programming updates via in-clinic sessions and subjects who additionally have the option of receiving programming updates via Virtual Clinic sessions. The study intends to demonstrate shorter times to achieve benefit in the Virtual Clinic cohort.
Sacramento, California and other locations
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
Sorry, not currently recruiting here
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.
Sacramento, California and other locations
Our lead scientists for Deep Brain Stimulation research studies include David Brandman, MD Kiarash Shahlaie, MD, PhD.
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