Degenerative Disc Disease clinical trials at UC Davis

3 in progress, 2 open to eligible people

Showing trials for

  • Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two-level Symptomatic Degenerative Disc Disease in the Cervical Spine.

    open to eligible people ages 22-69

    The study is a prospective, multi-center cohort study of patients with two-level DDD implanted with CDA adjacent to ACDF (hybrid construct). The overall success of the hybrid procedure will be compared to 2-level ACDF historical controls from the Mobi-C IDE trial. 97 patients will receive the hybrid surgery and will be followed for a minimum of 2 years.

    Sacramento, California and other locations

  • Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain

    open to eligible people ages 18 years and up

    The primary purpose of this study is to evaluate the efficacy of rexlemestrocel-L+HA compared to control in reducing low back pain at 12 months post-treatment and safety of a single injection of rexlemestrocel-L+HA injected into a lumbar intervertebral disc compared to control through 12 months post-treatment.

    Sacramento, California and other locations

  • P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation

    Sorry, in progress, not accepting new patients

    The aim of this trial is to evaluate if P-15L bone graft (investigational device) is not inferior in effectiveness and safety to local autologous bone (and allograft where necessary) as an extender (control device) when applied in instrumented transforaminal lumbar interbody fusion (TLIF) in subjects with degenerative disc disease (DDD). In addition to the general overall objective, a sub-group analysis will be performed on the high-risk subject population (tobacco use, obesity, diabetes), as previous studies have shown negative effects of smoking, obesity and diabetes on fusion and bone healing, increased peri/postoperative complications, and lower patient-reported outcome scores.

    Sacramento, California and other locations

Our lead scientists for Degenerative Disc Disease research studies include .

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