Epilepsy clinical trials at UC Davis

6 in progress, 2 open to eligible people

Showing trials for

  • NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))

    “A first in human stem cell implantation surgery for drug resistant Temporal Lobe Epilepsy”

    open to eligible people ages 18-75

    This clinical trial is designed to test whether a single image-guided intracerebral administration of inhibitory nerve cells, called interneurons (NRTX-1001), into subjects with drug-resistant unilateral mesial temporal lobe epilepsy (MTLE), with or without mesial temporal sclerosis (MTS), is safe (frequency of adverse events) and effective (seizure frequency). NRTX-1001 comprises human interneurons that secrete a neurotransmitter, gamma-aminobutyric acid (GABA).

    Sacramento, California and other locations

  • Sleep Architecture & Cognition in Focal Epilepsy

    open to eligible people ages 18-40

    Focal Epilepsy (FE) patients and healthy controls will wear an actigraph at home for one week and a home sleep study device at home for one night. Participants will then undergo two nights of testing (at least one week apart) at California Sleep Solutions (CSS) in Sacramento, CA. During the overnight stays, participants will have EEG leads placed and possibly a headband. They will undergo cognitive testing before they go to sleep and again in the morning. During one night of testing, sounds will be played in the room (acoustic stimulation). The sounds should not wake the participants.

    Sacramento, California

  • XEN1101 in Epilepsy

    Sorry, accepting new patients by invitation only

    This study will evaluate the long term safety, tolerability, pharmacokinetics (PK), and efficacy of XEN1101 in subjects with Focal Onset Seizures (FOS) or Primary Generalized Tonic-Clonic Seizures (PGTCS) for the treatment of seizures for up to 6 years.

    Sacramento, California and other locations

  • Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy

    Sorry, in progress, not accepting new patients

    This study plans to evaluate the time course of inflammation in the brain after a moderate to severe traumatic brain injury using positron emission tomography (PET) brain imaging. Patients will undergo PET scans of the brain at two weeks and two months after injury to measure neuro-inflammation. The results of the PET scans will be analyzed and correlated with the risk of post-traumatic epilepsy.

    Sacramento, California

  • Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Seizures

    Sorry, in progress, not accepting new patients

    Primary objective: To evaluate the safety and tolerability of cenobamate in pediatric subjects 2-17 years of age with partial-onset (focal) seizures

    Sacramento, California and other locations

  • Temporally Interfering Electric Field Stimulation in the Treatment of Epilepsy

    Sorry, accepting new patients by invitation only

    This study investigates the potential for temporally-interfering electric field stimulation (TIEFS) to treat epilepsy. In this case series within and between subjects design, the impact of TIEFS on epilepsy biomarkers was studied in patients with medial temporal lobe epilepsy. Secondary analyses examine the underlying physiological effects of TIEF on local brain activity and brain networks.

    Sacramento, California and other locations

Our lead scientists for Epilepsy research studies include .

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