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Osteoarthritis clinical trials at UC Davis
2 research studies open to eligible people

  • An Observational Study Testing Long-Term Treatment With Experimental SM04690 in Patients With Osteoarthritis of the Knee

    “This study will monitor the long-term safety and effectiveness of the study drug SM04690 or placebo that was previously given to you.”

    open to eligible people ages 40-80

    This long-term extension study is designed to monitor the long-term safety, tolerability, and efficacy of treatment of SM04690 or placebo previously injected in the target knee joints of subjects with moderately to severely symptomatic osteoarthritis (OA) from a Samumed-sponsored SM04690-OA phase 2 or phase 3 study. No additional SM04690 or placebo therapy will be administered in this study.

    Sacramento, California and other locations

  • Study to Determine the Safety and the Effectiveness of Experimental Fasinumab in Patients With Knee or Hip Osteoarthritis Pain

    “This study is being done to see how effective and safe fasinumab (REGN475) is for the treatment of pain caused by Osteoarthritis.”

    open to eligible people ages 18 years and up

    The primary objective of the study is to evaluate the efficacy of fasinumab compared to placebo, when administered for up to 24 weeks in patients with pain due to osteoarthritis (OA) of the knee or hip. The secondary objectives of the study are: - To evaluate the efficacy of fasinumab compared to non-steroidal anti-inflammatory drugs (NSAID)s, when administered for up to 24 weeks in patients with pain due to OA of the knee or hip - To assess the safety and tolerability of fasinumab compared to placebo and compared to NSAIDs, when administered for up to 24 weeks in patients with pain due to OA of the knee or hip

    Sacramento, California and other locations

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