for people ages 18 years and up (full criteria)
at Sacramento, California and other locations
study started
estimated completion



The overarching goal of this UH2-UH3 proposal is to work with the NIH Health Care Systems Research Collaboratory to develop and implement a large scale, cluster randomized pragmatic clinical trial demonstration project that directly informs national trauma care system policy targeting injured patients with presentations of Posttraumatic Stress Disorder (PTSD) and related comorbidity. Each year in the United States (US), over 30 million individuals present to trauma centers, emergency departments, and other acute care medical settings for the treatment of physical injuries. Multiple chronic conditions including enduring PTSD, alcohol and drug use problems, depression and associated suicidal ideation, pain and somatic symptom amplification, and chronic medical conditions (e.g., hypertension, coronary artery disease, diabetes, and pulmonary diseases) are endemic among physical trauma survivors with and without traumatic brain injuries (TBI). Evidence-based, collaborative care/care management treatment models for PTSD and related comorbidities exist. These care management models have the potential to be flexibly implemented in order to prevent the development of chronic PTSD and depressive symptoms, alcohol use problems, and enduring physical disability in survivors of both TBI and non-TBI injuries; care management models may also be effective in mitigating the impact of the acute injury event on symptom exacerbations in the large subpopulation of injury survivors who already carry a substantial pre-injury burden of multiple chronic medical conditions.


Posttraumatic Stress Disorder Depression Alcohol-Related Disorders Suicidal Ideation Substance-Related Disorders Mild Cognitive Impairment Quality of Life Pain Wounds and Injury Brain Injuries Chronic Disease Disease Cognitive Dysfunction Stress Disorders, Post-Traumatic Wounds and Injuries Diphenhydramine Prazosin Duloxetine Hydrochloride Mirtazapine Trazodone Fluvoxamine Fluoxetine Paroxetine Venlafaxine Hydrochloride Citalopram Motivational Interviewing Cognitive Behavioral Therapy Elements Care Management Setraline Venlafaxine Duloxetine


You can join if…

Open to people ages 18 years and up

  • Patient currently admitted to inpatient/emergency department for a traumatic injury

You CAN'T join if...

  • Non-English speaking
  • Self-inflicted injury
  • Actively psychotic
  • Incarcerated or in custody
  • Less than 35 on PTSD Checklist
  • Less than 3 items on PTSD medical record screen
  • Less than 2 pieces of contact information


  • U.C. Davis not yet accepting patients
    Sacramento California 95816 United States
  • Santa Clara Valley Medical Center not yet accepting patients
    San Jose California 95128 United States


accepting new patients
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Completion Date
University of Washington
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