at San Francisco, California and other locations
study started
estimated completion



The APOLLO study is being done in an attempt to improve outcomes after kidney transplantation and to improve the safety of living kidney donation based upon variation in the apolipoprotein L1 gene (APOL1). Genes control what is inherited from a family, such as eye color or blood type. Variation in APOL1 can cause kidney disease. African Americans, Afro-Caribbeans, Hispanic Blacks, and Africans are more likely to have the APOL1 gene variants that cause kidney disease. APOLLO will test DNA from kidney donors and recipients of kidney transplants for APOL1 to determine effects on kidney transplant-related outcomes.

Official Title

APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)


The National Institutes of Health (NIH)-sponsored collaborative APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) is charged with prospectively assessing the effects of renal-risk variants (RRVs) in the apolipoprotein L1 gene (APOL1) on outcomes for kidneys from donors with recent African ancestry and the recipients of their kidneys, after deceased- and living-donor renal transplantation. For the purposes of APOLLO, recent African ancestry is defined as individuals with similar genetic make-up to those currently residing in Africa. APOLLO will also study the impact of APOL1 RRVs on the health of living kidney donors with recent African ancestry.


Kidney Diseases, Kidney Failure, Kidney Disease, Chronic, Apolopoprotein L1 gene (APOL1), Kidney Transplantation, Kidney Donor, United Network for Organ Sharing (UNOS), Association of Organ Procurement Organizations (AOPO), Kidney Transplantation Outcomes Network, Renal Insufficiency, Chronic Renal Insufficiency, Recipients of a Kidney Transplant, Living Kidney Donors


You can join if…

for Living Donors:

- Living kidney donors with self-reported recent African ancestry (defined as African American, Afro-Caribbean, Hispanic black or African) will be eligible for inclusion.

You CAN'T join if...

for Living Donors:

- Participants who are unable or unwilling to provide informed consent. Inclusion Criteria for Recipients: - Recipients of a kidney transplant from an eligible living or deceased donor with recent African ancestry. - Recipients of multi-organ transplants including a kidney plus an additional organ (i.e. liver, heart, lung, pancreas, etc.) or pediatric en bloc and dual kidney transplants. Exclusion Criteria for Recipients: - Participants who are unable or unwilling to provide informed consent.


  • University of California San Francisco accepting new patients
    San Francisco California 94143 United States
  • Saint Louis University Center for Transplantation accepting new patients
    Saint Louis Missouri 63104 United States


accepting new patients
Start Date
Completion Date
Wake Forest University Health Sciences
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Study Type
Expecting 5000 study participants
Last Updated