A Study of Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) in Kids

a study on Oxygen Deficiency Desaturation of Blood Hypoventilation Anesthesia Hypoxia

Summary

Eligibility
for people ages up to 18 years (full criteria)
Healthy Volunteers
healthy people welcome
Location
at Palo Alto, California and other locations
Dates
study started
completion around

Description

Summary

THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia. The use of high-flow nasal cannula oxygen supplementation during anesthesia for surgical procedures has been a recent development in the adult population, with limited data analyzing the pediatric population. This study will determine whether high flow nasal cannula oxygen supplementation during surgical or endoscopic procedures can prevent desaturation events in children under anesthesia and improve the outcomes of that surgery.

Official Title

Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Use in Pediatric Populations: A Randomized Prospective Multi-Site Trial

Keywords

Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect, Hypoxia, Transnasal Humidified Rapid-Insufflation Ventilatory Echange

Eligibility

You can join if…

Open to people ages up to 18 years

  • Pediatric patients less than 18 years of age undergoing general anesthesia for procedures or surgeries

You CAN'T join if...

  • Pregnancy
  • Absence of parent or legal guardian able to provide written consent for study participation
  • Anatomical or surgical contraindications (epistaxis, basilar skull fractures or abnormalities, nasal surgery or obstruction, nasal fractures, nasal vascular abnormalities), tracheostomy tube
  • Emergent surgery for which application of HFNC might delay surgery or might result in increased aspiration risk.

Locations

  • Lucile Packard Children's Hospital Stanford
    Palo Alto California 94304 United States
  • Lurie Children's Hospital of Chicago
    Chicago Illinois 60611 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Stanford University
Links
Sign up for this study
ID
NCT04322994
Study Type
Interventional
Participants
Expecting 500 study participants
Last Updated