Summary

Eligibility
for people ages 18-75 (full criteria)
Location
at Sacramento, California and other locations
Dates
study started
estimated completion

Description

Summary

The primary objective for this trial is to determine the effect of GB002 (seralutinib) on improving pulmonary hemodynamics in subjects with World Health Organization (WHO) Group 1 PAH who are Functional Class (FC) II and III. The secondary objective for this trial is to determine the effect of GB002 (seralutinib) on improving exercise capacity in this population.

Official Title

A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Clinical Study to Evaluate the Efficacy and Safety of Oral Inhalation of GB002 for the Treatment of WHO Group 1 Pulmonary Arterial Hypertension (PAH)

Keywords

Pulmonary Artery Hypertension seralutinib Pulmonary Arterial Hypertension Hypertension GB002 (seralutinib) Generic Dry Powder Inhaler

Eligibility

You can join if…

Open to people ages 18-75

  1. A current diagnosis of symptomatic PAH classified by one of the following:
  2. Idiopathic PAH (IPAH) or heritable pulmonary arterial hypertension (HPAH).
  3. PAH associated with connective tissue diseases.
  4. PAH associated with anorexigen or methamphetamine use.
  5. Congenital heart disease with simple systemic to pulmonary shunt at least 1 year after surgical repair.
  6. 6MWD ≥ 150 meters and ≤ 550 meters at screening.
  7. WHO FC II or III symptomatology.
  8. Treatment with standard of care PAH background therapies.
  9. Documentation of cardiac catheterization within the screening period that is consistent with the diagnosis of PAH and meeting all the following criteria, to be confirmed by a central hemodynamic core laboratory:
  10. Mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg (at rest), AND
  11. PVR ≥ 400 dyne•sec/cm5, AND
  12. Pulmonary capillary wedge pressure (PCWP) or left ventricular-end diastolic pressure (LVEDP) ≤12 mm Hg if PVR ≥400 to <500 dyne∙sec/cm5 OR
  13. PCWP or LVEDP ≤15 mmHg if PVR ≥500 dyne∙sec/cm5
  14. Pulmonary function tests (PFTs) and diffusing capacity of the lungs for carbon monoxide (DLCO) at screening with the following criteria met:
  15. Forced expiratory volume in 1 second (FEV1) ≥60% (predicted);
  16. DLCO ≥40% predicted except for subject with PAH associated with systemic sclerosis (SSc-APAH) where DLCO ≥30% is required.

You CAN'T join if...

  1. Evidence of chronic thromboembolic disease or acute pulmonary embolism as assessed by ventilation-perfusion (V/Q) scan, computed tomography (CT)-angiogram, or pulmonary angiogram prior to screening.
  2. Uncontrolled systemic hypertension as evidenced by sitting systolic blood pressure > 160 mm Hg or sitting diastolic blood pressure > 100 mm Hg during screening visit after a period of rest.
  3. Systolic blood pressure < 90 mm Hg during screening and baseline visits.
  4. WHO Pulmonary Hypertension Group 2-5.
  5. Human immunodeficiency virus (HIV)-associated PAH.
  6. History of left-sided heart disease and/or clinically significant cardiac disease.
  7. Untreated severe obstructive sleep apnea.
  8. History of atrial septostomy within 180 days prior to screening.
  9. Pulmonary venous occlusive disease (PVOD).
  10. . Subjects with a history of portopulmonary hypertension or portal hypertension classified as Child-Pugh Class A or higher; or baseline ALT or AST > 2 x ULN or Total Bilirubin ≥ 2 x ULN.
  11. . History of malignancy within 5 years prior to screening.
  12. . History of a potentially life-threatening cardiac arrhythmia with an ongoing risk.
  13. . Severe acute or chronic medical or laboratory abnormality that may increase the risk associated with study participation or IP administration (eg; history intracranial hemorrhage).
  14. . Chronic renal insufficiency as defined by an estimated glomerular filtration rate (eGFR) < 45 mL/min/1.73m2 via Chronic Kidney Disease Epidemiology Collaboration (CKD-epi) at screening or requires dialytic therapy or hemofiltration.
  15. . Hemoglobin (Hgb) concentration < 8.5 g/dL at screening.
  16. . Evidence of active HIV, Hepatitis B or Hepatitis C, or tuberculosis (TB) infections.
  17. . Inhaled prostanoids; these drugs may be withdrawn ≥ 4 weeks prior to or at screening, if clinically indicated.
  18. . Use of oral anticoagulants (ie, coumadin or NOAC) at randomization.
  19. . Requirement of intravenous (IV) inotropes (ie, levosimendan, dopamine, dobutamine, milrinone, norepinephrine) other than an IV prostanoid within 4 weeks of screening.
  20. . Prior participation in GB002 studies and/or prior treatment with GB002.
  21. . Currently participating in or has participated in a study of an investigational agent or has used an investigational device for the treatment of PAH within 4 weeks prior to screening.
  22. . Current use of inhaled tobacco and/or inhaled marijuana.
  23. . Documented history of alcohol abuse and/or positive test for drugs of abuse (amphetamines, methamphetamines, cocaine, phencyclidine [PCP]).
  24. . Subjects with a history of severe milk protein allergy. In addition, subjects with known intolerance or hypersensitivity to lactose who, in the opinion of the investigator, may experience severe symptoms following the ingestion of lactose.
  25. . QTcF of > 480 msec recorded on a screening or baseline ECG or receiving concurrent treatment with medications that prolong QT interval.
  26. . Have any other condition or reason that, in the opinion of the Investigator or Medical Monitor, would prohibit the subject from participating in the study.

NOTE: Additional inclusion/exclusion criteria may apply, per protocol.

Locations

  • UC Davis Medical Center accepting new patients
    Sacramento California 95817 United States
  • The University of California San Francisco accepting new patients
    San Francisco California 94143 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
GB002, Inc., a wholly owned subsidiary of Gossamer Bio, Inc.
Links
Sign up for this study
ID
NCT04456998
Phase
Phase 2
Study Type
Interventional
Last Updated