Help Us Find New Ways to Treat Adolescent Depression — Join Our Brain Stimulation Pilot Study!

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a study on Depression Suicidal Ideation Attempted Suicide

Summary

Eligibility
for people ages 15-25 (full criteria)
Location
at Sacramento, California
Dates
study started
study ends around
Principal Investigator
by Se Ri (Sally) Bae, MD

Description

Summary

The goal of this clinical trial is to learn if a fast-acting brain stimulation treatment called transcranial magnetic stimulation (TMS) can help people with depression and suicidal thoughts. The treatment is non-invasive (does not involve surgery or medications), is given over 5 days, and uses brain imaging (MRI) to guide which part of the brain to target. This study tests whether this treatment is a helpful and practical option for adolescents and young adults who are depressed and have suicidal thoughts.

We want to see if:

  1. This treatment is feasible and acceptable to patients
  2. It can reduce depression and suicidal thoughts
  3. It can lower the chance of going to the hospital
  4. It affects daily functioning (school, work, relationships)

All participants will undergo 5-days of TMS treatment and complete MRI brain scans before and after treatment. They will return for check-ups after 1 week and 4 weeks.

Official Title

Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk

Keywords

Major Depressive Disorder (MDD), Suicidal Ideation, TMS, MDD, transcranial magnetic stimulation, Major Depressive Disorder

Eligibility

You can join if…

Open to people ages 15-25

  • English speaking
  • Able to provide informed consent
  • age 15-25 years
  • Discharged within the past week from the ED for chief complaint of SI OR recently admitted in urgent health care setting or seen in outpatient clinic for depression-related suicidal ideation
  • Meets MDD criteria per the Mini International Neuropsychiatric Interview (MINI)

You CAN'T join if...

  • Unable to consent (due to medical condition, psychosis, substance use, etc)
  • Use of benzodiazepines or medications that would interfere with TMS treatment as per PI discretion
  • Active substance use or severe substance use that in the opinion of the PI would interfere with study participation
  • Untreated, active psychosis
  • Female patient who is breastfeeding, pregnant or who is planning a pregnancy during the study
  • Participation in any clinical study with exposure to any investigational treatment or product within the previous 30 days, or plan on concurrent participation in other studies
  • Contraindications to receiving TMS and/or MRI as determined by screening questionnaires

Location

  • UC Davis Medical Center accepting new patients
    Sacramento California 95817 United States

Lead Scientist at UC Davis

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Davis
Links
Sign up for this study
ID
NCT07025720
Study Type
Interventional
Participants
Expecting 25 study participants
Last Updated
Contact us about this trial