Genetic Basis of Moles (Melanocytic Nevi)

Help us discover the genetic basis of moles.

a study on Melanocytic Nevi

Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at Sacramento, California
Dates
study started
completion around
Principal Investigator
by Maija Kiuru, MD
Headshot of Maija Kiuru
Maija Kiuru

Description

Summary

The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens.

Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples:

  1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis.
  2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.

Official Title

Genetic Basis of Melanocytic Nevi

Keywords

Melanocytic Nevi, Nevus, Pigmented Nevus, Epithelioid and Spindle Cell Nevus, Collecting Nevi

Eligibility

You can join if…

Open to people ages 18 years and up

  • Male or female subjects that are 18 years or older
  • Subjects with melanocytic nevi\

You CAN'T join if...

  • Patients less than 18 years of age
  • Patients without melanocytic nevi
  • Patients with a bleeding disorder or are taking anticoagulation medication

Location

  • University of California-Davis, Department of Dermatology accepting new patients
    Sacramento California 95816 United States

Lead Scientist at UC Davis

  • Maija Kiuru, MD
    My research interests include genetic alterations in skin tumors and familial skin diseases, with the aim of identifying genes relevant for understanding cutaneous and tumor biology, improving diagnostic methods, and identifying novel therapeutic targets. An ongoing theme has been gene discovery.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Davis
Links
Sign up for this study
ID
NCT03054584
Study Type
Observational
Participants
Expecting 50 study participants
Last Updated
Contact us about this trial