Brain & Beliefs Study

Help us understand how beliefs shape experiences and behavior during a completely non-stimulation sham procedure.

a study on Depression Transcranial Magnetic Stimulation

Summary

Eligibility
for people ages 15-25 (full criteria)
Location
at Sacramento, California
Dates
study started
study ends around
Principal Investigator
by Manpreet Kaur Singh, MD, MS

Description

Summary

The goal of this clinical study is to understand how a person's expectations about treatment can influence their mood, motivation, and reactions to everyday rewards. The study includes young people ages 15-25 who will complete a sham (placebo) version of an accelerated transcranial magnetic stimulation (TMS) treatment. No active brain stimulation is given.

The main questions this study aims to answer are:

  1. Do expectancy and treatment beliefs change during and after an accelerated sham TMS schedule?
  2. Do these expectations influence mood, reward processing, or craving?
  3. Does a more intensive schedule of sham sessions lead to different expectancy effects than a slower, once-daily schedule?

Participants will:

  • Complete baseline clinical assessments and an MRI session
  • Undergo five days of accelerated sham TMS (no active brain stimulation is delivered)
  • Complete post-treatment MRI and follow-up assessments at 1 week and 4 weeks

Official Title

Studies of Cognition and Behavior Using Sham Accelerated Transcranial Magnetic Stimulation

Keywords

Depression, TMS, Sham TMS

Eligibility

You can join if…

Open to people ages 15-25

  • English speaking
  • Able to provide informed consent (and assent if < 18 years)
  • 15-25 years old
  • Slight-to-severe symptoms of depression

You CAN'T join if...

  • Past exposure to Transcranial Magnetic Stimulation
  • Unable to consent (due to medical condition, psychosis, substance use, etc)
  • Acute suicidal crisis or with active medical illness that would interfere with participation
  • Contraindications to receiving MRI as determined by screening questionnaires (Contraindications for MRI include metal in the body related to an injury or surgery, for example, surgical clips, metal fragments in the eyes, or piercings that cannot be removed. Subjects with braces or permanent retainers will not be scanned, because the effects on image signal are not well understood and may affect comparability between subjects and scan sites. Participants will be excluded for major neurological problems, such as seizure disorder, traumatic brain injury with loss of consciousness, or sensory problems that may impair task performance, such as blindness.)
  • Participation in any clinical study with exposure to any investigational treatment or product within the previous 30 days, or plan on concurrent participation in other studies

Location

  • UC Davis Medical Center accepting new patients
    Sacramento California 95817 United States

Lead Scientist at UC Davis

  • Manpreet Kaur Singh, MD, MS
    Associate Professor, MED: Psychiatry & Behav Sci, School of Medicine. Authored (or co-authored) 175 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Davis
Links
Sign up for this study
ID
NCT07397858
Study Type
Interventional
Participants
Expecting 25 study participants
Last Updated
Contact us about this trial