for people ages 12-85 (full criteria)
at Sacramento, California and other locations
study started
completion around



The primary objective of this study is to evaluate the effect of brensocatib at 10 mg and 25 mg compared with placebo on the rate of pulmonary exacerbations (PEs) over the 52-week treatment period.

Official Title

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib Administered Once Daily for 52 Weeks in Subjects With Non-Cystic Fibrosis Bronchiectasis - The ASPEN Study


Non-Cystic Fibrosis Bronchiectasis, ASPEN, Brensocatib, INS1007, Bronchiectasis, Fibrosis, Brensocatib 10 mg, Brensocatib 25 mg


You can join if…

Open to people ages 12-85

  1. Provide their signed study informed consent to participate.
    1. Adolescent participants must have signed study assent form to participate, and the adolescent's parent or legal guardian must have provided signed informed consent for the adolescent to participate.
  2. Clinical history consistent with non-cystic fibrosis bronchiectasis (NCFBE) (cough, chronic sputum production and/or recurrent respiratory infections) that is confirmed by chest computerized tomography (CT) scan.
  3. At least 2 PEs defined by need for antibiotic prescription by a physician for the signs and symptoms of respiratory infections in the past 12 months before the Screening Visit.
    1. Adolescent participants are required to have at least 1 pulmonary exacerbation in the prior 12 months.
  4. Women must be postmenopausal (defined as no menses for 12 months without an alternative medical cause), surgically sterile, or using highly effective contraception (ie, methods that can achieve a failure rate <1% per year when used consistently and correctly) from Day 1 to at least 90 days after the last dose.
  5. Male participants with female partners of childbearing potential must be using effective contraception from Day 1 to at least 90 days after the last dose.
  6. Male participants with pregnant or non-pregnant women of child-bearing potential partners must use condoms to avoid potential exposure to the embryo/fetus.

You CAN'T join if...

  1. A primary diagnosis of chronic obstructive pulmonary disease (COPD) or asthma as judged by the Investigator.
  2. Bronchiectasis due to cystic fibrosis.
  3. Current smokers as defined per Centers for Disease Control (CDC).
  4. Known or suspected immunodeficiency disorder, including history of invasive opportunistic infections.
  5. Known history of human immunodeficiency virus (HIV) infection.
  6. Currently being treated for nontuberculous mycobacteria (NTM) lung infection, allergic bronchopulmonary aspergillosis, or tuberculosis (TB).
  7. Active and current symptomatic infection by 2019 corona virus disease (COVID-19).
  8. Inability to follow the procedures of the study (eg, due to language problems or psychological disorders).
  9. Receiving medications or therapy that are prohibited as concomitant medications.

    10. Previously participated in a clinical trial for brensocatib. 11. Received any live attenuated vaccine within 4 weeks prior to the first administration

    of brensocatib.

    12. Suffering an exacerbation 4 weeks before Screening or during the Screening period. 13. Adult participants only: Have compliance issues with completion of electronic diary

    entries during the Screening Period and in the opinion of the Investigator, compliance is unlikely to improve during the study.

    14. Participated in any other interventional clinical studies within 3 months before

    Screening Visit.

    15. History of alcohol or drug abuse within 6 months prior to the Screening Visit. 16. Is the Investigator or any Sub-Investigator, research assistant, pharmacist, study

    coordinator, other staff or relative thereof directly involved in the conduct of the study.

    17. Known history of hypersensitivity to brensocatib or any of its excipients.


  • USA024
    Sacramento California 95817-1460 United States
  • USA104
    Fresno California 93702 United States


accepting new patients
Start Date
Completion Date
Insmed Incorporated
Sign up for this study
Phase 3 research study
Study Type
About 1767 people participating
Last Updated